Hyaluronic acid is an essential component of connective tissue. It is present in the extracellular matrix of tissues, synovial fluid, and other bodily fluids. Its biological activity results from their interaction with growth factors, osmotic pressure regulation, and tissue lubrication. All of these functions support the preservation of the tissue's homeostatic and structural integrity. The majority of cells in the body produce hyaluronic acid, which is synthesized in the cell membrane by a membrane-bound protein and secreted into the extracellular space, primarily by fibroblasts, when endotoxins are present. In dentistry, hyaluronic acid has evidenced anti-inflammatory, antiedematous, antibacterial, and wound healing properties that are helpful in the treatment of many oral diseases like periodontitis, which is caused by various bacteria present in subgingival plaque with mechanical therapy that causes tissue regeneration. This type of treatment might benefit many individuals, particularly those who are predisposed to systemic disorders such as cardiovascular disease and diabetes caused by periodontal disease.